If you don't believe the CPU knows your plays, wait until you see them setting up for a blitz then audible to pass from the same formation if you called run, run if you called pass. Do it back and forth a few times.
Even though your formation does not change you'll see the CPU D realign each time you audible back and forth. Maybe not every time, but I had it happen to me last night. SO friggin' obvious the programming was cheating me, and this was on Varsity.