Take your time, make the extra pass, play solid paint defense, don't give up layups, force the jumper and you will be able to stay around to the end. Start getting frustrated and loose your focus, CPU will go on a run.
Other day I was up 58-50 Spurs (me) vs Clippers, 3rd quarter they got a big run 21-8, they were up 5, CP3 did work from mid range and they got a few stops, next thing I knew I was done 15, could never get closer than 10, ended up losing, 106-94
Point being, HOF is the ultimate test, the CPU will get some ish (can't do ish about it sometimes), take the L, move on to the next one. But with the V2.0 on 2k daily rosters, you can win and all it takes is to play smart and methodical.