But you don't want the mismatch mechanic to kick in when there is an actual center guarding Shaq. The game adapts well enough to threats, they front him they'll try to knock away the entry pass they'll double when he gets hot.
You definitely don't want the game to think of Shaq as a "mismatch" by definition. Then the CPU offense will override every play that could have been called and do a "quick post" for Shaq. It would treat Shaq as if Derek Fisher were guarding him and you don't want that.