Yep, those are absolutely 100% final. You can start your CFM with those settings, no changes will be coming in the near future.
Penalties will alter more than just calls per game. As weird as it sounds, altering penalty sliders actually effects overall gameplay too, so if you happen to make those changes you'll still get a challenging game but it might throw other aspects of gameplay off. We pretty much had to sacrifice penalties this year in order to get a better experience from the game.