Yep. For example, I'm playing as the Cowboys, and I want my LE to be a 4-3 Run Stopper rather than a 4-3 Edge Rusher as a I want to be stronger against the run in my base defense. This changes the OVR rating calculation for me for all LEs, the most immediate effect being that I now see Tyrone Crawford as having a better OVR rating than the default starter, George Selvie; the high-level indication to me being that for what I want out of my LE, I'd be better off playing Crawford. Which makes sense; Crawford has better ratings than Selvie in STR, BSH, and PMV, so he'd likely be the better player against the run anyway.
I have similar examples at other positions, but that's the best one I can offer because it resulted in me changing my depth chart.