Tackling can affect the running game and I personally feel that the running game works realistically well with this setting. You can tweak this to find the right balance if you like. It is just a base for now.
Any help is appreciated, its just of course time consuming. Still quite a bit of trial and error at the moment but I am getting closer each day. Finally feels as if Quarterbacks are playing like they should in Madden.
I have just seen your E Rated Sliders and they look very interesting, might have to try them out myself.