Try low reaction time with high PCV. Defenders still have the ability to cover well, but are less "psychic". I was actually able to "throw people open" as the CB's who weren't looking didn't suddenly respond to my button press....
Lowering both the OPI/DPI but leaving the OPI slightly higher makes the receivers more aggressive for me as well. I have mine at 20 DPI/25 OPI, but people have been getting good results with the numbers in the teens. That coupled with the Reaction time/PCV tweak in your sliders and the WR's are actually attacking the ball down the field. OPI/DPI lowered actually make the WR/DB interactions livable IMO.