That's exactly the problem I'm having. I had two 1st-and-third situations last night and I even paused the game to check the controls. First time I held LS towards 1b and held down L2, releasing it once the pitcher started his motion: both runners went. Second time I held LS towards 1b and pressed-and-released L2 once pitcher started motion - neither runner went. I just can't get it to work right. Using DEFAULT controls by the way.