A good play is Y-Trips HB Wk formation, Curls play. Shotgun formation with the HB and SE to the left of the QB and a TE and 2 WRs to the right. The two outside receivers run 10-yard hitch patterns while the WR in the slot runs a post. The TE and RB go to the flat on their respective side of the formation. If man, the hitch is nearly always open provided you throw the ball on time and a fast slot WR may beat the nickle CB. If Cover 2 zone, the post-hitch action is similar to a smash concept in that the CB defending the strong side will likely get drawn up by the TE to the flat while the safety will likely take the post. If the S plays the hitch on the right and the weak safety covers the post (unlikely), the SE is likely open on the hitch. If all three are covered, you dump the ball to the TE or HB and possibly gain enough yardage where you can consider going on 4th or improve field position for the kick.
Another is Normal Y-Flex formation, HB Flare play. Another shotgun formation with 11 personnel. The TE and HB are on the right side of the QB with the TE in the slot. 2 WRs left and a WR right. The left outside receiver runs a GO, the WR in the slot runs a 5 -- 7 yard out, the TE runs a slant while the right outside WR runs a hitch. The TE is usually open on this play over the middle because both safeties are concerned with the outside WRs.
I don't recall the name of the formation or play off the top of my head, but there is another good Shotgun with 11 personnel play for zone coverage (or man with a good receiving / balanced TE). The TE lines up next to the RT with a flanker to his right. The TB is to the left of the QB with two WRs on the left of the formation. This play is a simple concept where you are almost always throwing to the right side (which is why I don't remember what the SE is doing). The TE and slot WR on the left run angle routes while the FL on the right runs a DIG. If the MLB follows the TE, the DIG is always open against zone. If the MLB doesn't follow the TE, the TE is open. The slot WR's angle route takes the weakside safety out of the play.