I am using your sliders with some adjustments. Both user and CPU are set to your user sliders. All penalties are default except roughing the passer which is off. 25 second countdown clock.
With Iowa State this is the first season I'll make a bowl game. Run sliders are fine. I use pistol formations - go to formation is pistol spread but others work also. The key is offensive line and running backs but you have to run the ball to get the recruits. I focus on the run game and it takes a good team to stop my running game and the focus on the run attracts linemen and backs.
On defense I blitz a lot on passing downs.
Sliders post patch are better than pre patch. I can post some results if you would like.