Laurie Metcalf is an accomplished actress who has no problem playing any role big or small. She has won three Emmys, a Tony, and received an Academy Award nomination this year.
EDIT: "The opening of the episode was the best part. Wasn't expecting that at all. LOL, she literally does put the KARA in Karaoke."
LOL, that went over my head even with the KARA caps.
It's important to bring recognition to the disease but I wish they would have pulled the Martian Alzheimer angle.

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