I'd say that's when you just need 2 things:
1) The ability to go up with either hand
2) And the strength to fend off the defender with your arm/shoulder/body on the other side
If you go can up with the other hand, the only option they've got is to foul you. It especially helps if you can get "under" them, effectively cutting them off from the basket, giving you a clear lane.
For instance, if I beat a guy off the dribble going left, and he's staying somewhat close to me, but I've got a step, I won't just go straight to the basket, because then I'm also giving him a clear lane at the basket and a chance to get his hands into me or to block the shot. Instead, I'd veer slightly back inside or use a hop step to get myself between him and the basket, and then use my momentum to finish. For instances like that, if you can do a layup "right next" to the basket, that helps. As in, just a split second after you release, your hand is basically hitting the backboard. That leaves very little time for the ball to be swatted away, and you're using the rim to block anyone trying to come from the weakside.
I am not sure if that helped at all

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