With Vann's playbooks, Run Plays at 100 makes the offense more fluid and the ball really gets passed around. Everyone gets their shots, but the superstars still stand out in-game and on the stat sheet.
Without Vann's playbooks, there were a lot of broken plays, and with Run Plays at 0 the AI seemed to bypass those plays.
Whatever the "science" is behind this slider, all I know is that with Vann's playbooks the game plays best with Run Plays at 100.
Interesting, I'll be sure to give this a look some time.
Unfortunately I may not be able to update my set for a while. Not only do I have a ridiculous amount of school-work coming up, but also Far Cry 3 comes out tonight and I have a feeling that that game will consume ALL of my free time for a while...