The only time I was beaten by the CPU in the past is when it went into robo-superman-mode and the QB would knock of 2 DEs while tossing a 5 yard pass that bounces off a defender into the arms of a WR who breaks 12 tackles on the way to the endzone. Heh. I exaggerate but not much.
What I would look for in the game of the future is a field position battle. Where punting is actually a part of the game. Where moving the ball 20 yards and only getting a FG was a victory rather than a failure. Where having an efficient ground game (or running the ball) isn't a penalty.
Now, the AI is scripted (at least on runs) for the linemen to ignore the oncoming backers ... which is just ... well, wrong.