http://www.youtube.com/watch?v=_F7X19Y8gEM
First problem, has been mentioned many but still not enough times, route mirroring. The DB runs the route better than the WR. Along with this problem is the locomotion of route running. For some reason, the route running locomotion carries a lot more weight and momentum than the defensive locomotion as shown in the video. This is a small problem but has a chain reaction to cause enormous problems such as excessive BS ints. And the last but not least problem is the dreaded catch animation speed burst. Positioning means nothing. The game simply decides what is going to happen and makes it happen no matter how the players are positioned. This is not Simulation Football.