I used to throw to guys that I had a clear line of sight to, but now I've started fitting passes over short defenders a lot more, especially on corner and deep out routes. I've had a ton of success running Flood and Z Spot out of trips by just adding the slightest bit of touch and directional aiming you can fit it over the short zones and have a ton of success.
Obviously it isn't something I'd risk with a poor QB, but I run a Dana Holgorsen air raid out of Pistol/Gun and my QB's have been Weeden and Chelf at Okie State, a very developed Tajh Boyd and now 99 throw accuracy Cole Stoudt as a JR at Clemson and then Bryant Moniz at Hawai'i. My goal is to recruit a B THP/THA QB every two years in my dynasties so when they are ready to start, they are in the 90's in both.