Dont give up! I was at the point of giving up and am so glad I did not. Here are a few things to help you out.
1. Change the sliders if you want to make it easy. Put human power all the way up, human contact, and solid hits, and if you have trouble recognizing pitches you can change the pitcher strike frequency all the way up too. I did this and go 4-4 and 2-4 every game!
2. Next is go into practice mode. Work on hitting and eventually you will get it.
3. This one is also very important, I had this problem. Your tv may be too big and is causing lag. So the pitch looks alot faster then it really is. There are 2 things you can do to solve this... You can get a new TV and hook up your ps3 to that or you can do something in the settings of your tv. I believe they have a forum on here for that.
4. I do not use guess pitch. The reason is because once you start using it you rely on it too much. But if I had to use it I would use classic 1/4 r default and guess fastball low. The reason is because most pitches are coming to the bottom part of the plate, and when he doesnt it will probably be down the middle.
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