I am close to really test the sliders in a full game and check out the full game stats. I am going with 15 Min quarters w/ 15 sec accel clock as well as rolling with All-Madden to see how it does. The biggest influence on the CPU play calling really seems to be USER Pass Defense Reaction.
USER rushing may be quite difficult and the CPU Block Shedding and CPU Tackle may need to come down. It's that high because I wanted to minimize the ability for the USER to exploit the outside run. I tried to compensate by putting USER Broken Tackles up to 50. Will see how this works for a few games I am not the best rushing and I will be using Shonn Greene so definitely if you are a good Madden rusher I'd like feedback on that.
Besides that the main thing I want to look good stat wise is a realisitc CPU completion percentage (60%-65% range) as well as amount of plays (120), Time of Possesion (30:00) and teams Passing Yards per game (230) + Attempts (34) and Rushing Yards per game (120) + Attempts (27). Teams should average around 22 Points per game give or take for some of the worse or better teams of course.
2012 Team Stats
http://www.teamrankings.com/nfl/team-stats/