Your right about the big DE's getting sacks in M10, not realistic, but ends up being fun I guess. I'm thinking for a variety I'm going to draft three "very" big D-lineman for my next chise and see how that works in the 3-4. Essentially draft all DT's with 90+ strength and use them as the three down lineman. It will hurt speed-wise, but I have found that the big strong guys break thru the O-line quicker than the smaller fast guys? Certainly not what we see in the NFL, but hey, we have to play with what Madden gives us!
I won't be able to do it in one draft but I'm thinking three monsters in the size range of 6'4" +, and 325 lbs+ .... then put some nice speedy LB's behind them. Again, not exactly what they do in the NFL (3-4 DE's are typically closer to 280-300 lbs), but might work well in Madden?