i usually take a LB thats blitzing and hot route him to a qb spy so i can fully controll, then right after the snap look for the slightest opening in the line and hit it full force. sometimes you get stuffed by a lineman but other times free shot at the QB.
using strong DT's is another way, if they have a good power move rating then its almost unfair.. just hit the right stick down and have at it
getting pressure with a 4-3 DE is tougher in this game because the animation for power moves>>>>>>>> the animation for finesse moves. it doesn't mean you won't ever get pressure with a DE, sometimes you will, alot of those times the cpu controlled DT will get there right before your DE
and as far as DE's go its alot easier to use a LE than a RE my best strat is to control your LE and hit right or left on the stick and sometimes you'll swim right by.