How about illegal man downfield? Oh wait EA says they program the Oline to not do that so it never happens. Also either edit the stupid "im getting hit and dont want to take the sack so i magically throw a super weak ball BACKWARDS" animation/cheat for the computer or call it correctly. Its a fumble and live if the QB throws the ball backwards. Happens all the time. When my QB is doing that however it weakly goes forward and is one handed intercepted by a D-lineman.
Oh and not as much a penalty but for the love of God. MEDICAL REDSHIRTS!!! Very easy to program into the game. Please do it if my stud player can be lost for the year with that nasty broken vertebrae.