Yea for sure, I did that last year... Hagg was my #3 CB and #2SS, so he was always in the game. Whenever he was in my nickel package, I used him in run support and blitzing.
I haven't started it yet this year, but last year I got a ton of great custom looks out of the 4-2-5 using defensive hot routes but I'm having trouble getting back into the groove. I almost exclusively play manually with Rickey Thenarse at FS, I tend to spread my LB's and walk Rickey up to a hybrid FS/LB position, like Urlacher at Lobo-back in UNM's 335. From there, I can pretty quickly back pedal into a zone, cover sideline to sideline and provide middle run support.
I just wish EA developed the blitz packages in 4-2-5 a bit more, they are really weak. The best blitz packages in the game are in Nickel 3-3-5 now, I run Nickel 3-3-5 almost exclusively on 3rd down.