Part of the frustration of football is struggling to stop the other team. I'm not sure you will completely stop the pass, but there are a few things you can do.
Pressure is the best way to do this. I use nickel 2-4-5 a good bit and cover 2. I press the receivers and user the MLB. Learn the plays the CPU like to run.
They love to run stick. They beat cover 2 with corner routes so be careful with that.
On third and 5+ they may run the RB screen. You can read this and pick it off or be in position for a tackle. In man, they love running corner routes as well and they also run smash where the outside receiver goes on a streak and the inside runs an out route. In man the out route is almost always open for them so you have to get pressure if you're running man.
When I run man, there's usually 3-4 rushers and I user the player who is covering the runningback. If the RB doesn't go out, I'll either rush or back off in to a middle zone/spy.
Learning what your coverages are supposed to do if you don't already know is a good idea. If they're tearing up your zone, maybe run cover 2 man, press the receivers, put your safeties in yellow or purple zones instead of blue, and then rush an extra man. There's risk/reward obviously, but if your DBs can get a good press in, you can force the QB in to a mistake.