When did Chelsea lose to Sunderland?
The problem in FIFA is alot of the 'upsets' i've seen are away victories with high margins - example, Man Utd lost 0-3 at home to Everton and 1-5 at home to Blackburn in my MM. In that same season, Blackburn finished rock bottom of the league.
Also, it doesn't appear that the big CPU teams are active in signing big name stars or realistic players in the off season. Man Utd didn't sign anyone after the end of my first season with City and if you recall they finished 10th in the league...Liverpool, who came 8th that same season, only signed Kompany (from me!) and no-one else (Utd did make random offers for stars like Adebayor and Robinho who were transfered listed though).
Real Madrid and Barcelona had exactly the same starting line-ups as they do in real life today when i faced each in the ECC in the 2011/12 and 2012/13 seasons respectively in the game. AC Milan's signing of Clichy is probably the most noteworty CPU-to-CPU signing after 4 full seasons (was made before the 2nd season) and it was good to see him in the starting lineup when i played Milan in ECC in 11/12, but that's really all i've come across.