Spread, spread, spread the LBs & D-line. Barton, Harris, and Romo aren't terrific run-stoppers, and you always need lots of gang-tackling. If Barton is alone on the outside against a half-decent RB (A-Train, TJ Duckett, or any power back,) the RB'll easily break the tackle every time. Usually, if you open up the line & LBs, you'll get Brayton or Grant in to help out, and they're strong enough to bring down the back. Telling your D-line to "fan" also helps contain the outside run. This opens up the inside, of course, but you can hope your opponent doesn't have the right audibles
Parrella's a decent run-stuffer, though, so it'll be harder through the middle. I usually get hit harder on weak-side runs, though, since Buchanon's much easier to slip tackles against.
I almost never blitz my LBs/CBs, though -- any LB blitz ends up with my LBs in the backfield when the back's already swept to the outside, and CB blitzes are ineffectual for the most part. Safety blitzes can sometimes help, and relying on CWood/Buchanon/RWood to cover receivers while Gibson blitzes usually works well enough to defend against the pass. Also, if you've spread your line, then sometimes a safety blitz can help clean up in the middle.
And lastly, watch your formations. The 5-2 formation isn't bad, since then you get Cooper in the middle to allow you to spread further. I prefer that to Goalline because the Raiders don't have a Goalline fan for the d-line, which means that the back will make it to the outside and have only one safety to beat. 3-4 sometimes works, but the Raiders just don't have that many dominant tacklers at LB. I usually play a 4-3 man defense -- zone sometimes works, but since the front four never gets much pressure, it more often just means a good receiver will break wide open.
But anyways. This works against B-list backs, like the Edgerrin Jameses, the William Greens, and so on. I just can't stop guys like Tomlinson or Shaun Alexander consistently, but I figure neither can the real Raiders
(Actually, the real Raiders can't even stop the Jerome Bettises of the world, so I should feel pretty good.
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And also, when I'm controlling the LB who's covering the RB, I usually let the CPU control the first several steps of the coverage, so that I don't have to guess direction? It works pretty well.