Be very careful... Both the in-game and playbook sub screens are broken this year. Some players will sub in and others won’t. If you use the in-game sub screen, players get stuck in certain positions, and you have to manually un-sub them with each new game. Last year it defaulted back to the original lineup after every game, but not always this year. So your roster can get permanently bunged up if you use the in-game sub screen.
I went through two rosters before finally figuring out the problem. So I created custom playbooks, and do all my subbing in there now so my rosters don’t get ruined. Do not use the in-game sub screen to sub players or you’ll risk permanently screwing up your roster. Use the depth chart and custom playbooks to make substitutions. If fact, make a copy of your created playbook as well. A couple of weeks ago my playbook mysteriously self-destructed – the WR was stuck in the FB position and the game wouldn’t let me sub him out. I had to make a whole new playbook because of it.