I think it really shouldn't matter (which difficulty should CPU play on when they against each other, and how do you assign difficulty level to each when putting the game on CPU vs. CPU?). But my setting is usually just on All-star when playing CPU vs. CPU.
Each spreadsheet "tab" tests different set of sliders, so I create a new tab when I make changes to sliders, so that the status I see on each tab correspond to setting I want to test. For each tab, sliders are fixed.

Last years playoffs were extremly interesting the way the bullpens were used.
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