Yeah, in general de-buffing bosses is pretty effective because all but a couple in the whole game are susceptible to them. And make sure you're doing direct commands on everyone so you can use the whole party's buffs/debuffs. The AI can handle most regular fights, but it kinda falls apart at times during boss fights and makes them tougher than they'd otherwise be.
Also, the boss you're fighting is level 45, so if you're considerably below that you might need to spend a little time time levelling yourself or your personas.

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