Presuming "equal" teams, I think the real differentiator between winning and losing is discipline on the part of the player. If you are ruthless and relentless in running P'n'R and starting over if you don't get what you want, you're going to win.
Because of inability to prevent help defense from the wing defender, and to govern behavior of the screener's defender without manually controlling both, almost no player can prevent a breakdown by one of those defenders multiple times in a row.
I often play way too loosely, especially because one of the things I sort of enjoy in Gauntlet is 1-on-1 ISO play. One of the easiest ways to get buckets in the game is to drive to the hole straightaway, creating a lane with a quick crossover. Especially if the opposing "PG" is defensively poor. And, to me, breaking guys down off the dribble is a lot more fun than running P'n'R.
And the latter is the problem, of course...not having good enough 3-point shooters. Even if one has 1 poor distance shooter, the post game can be a little frustrating, since help defense can come off the non-shooter with almost no risk.
I enjoy the post game in Gauntlet, but I try to avoid it unless they have a strong post defender (or I have a poor shooting team), otherwise it just feels too cheesy. It drives me nuts when someone just tries to bully in the post with a big mismatch, for an easy Post Hook.