im using pokes sliders too, so maybe i can help.
im doing a myleague with the knicks(real rosters, im using 2k's default rosters). however i am in year 2 and i have made some changes to the roster. i signed greg monroe and kostas koufas, i drafted kentucky center Karl Towns. i also made a trade to get kyle singler. i still have larkin, galloway, hardaway and carmelo.
now anyway, my offense is actually not all that succesful. but thats more in part to me missing tons of wide open jumpshots. if i could make more jumpers id be shooting a very high percentage.
my advice to you is:
1) practice your jumpshooting with all your players, and do it OFTEN. it is hard to make jumpers with these sliders. you need to be close to perfect on their releases. i also suggest bumping the 3 point shooting up from 47 to 48 with these sliders.
2) run plays. if you dont like the plays in your playbook, go edit them. running plays keeps your offense balanced and can be great for when you need to settle down and stop free lancing.
3) dont be afraid to break a play off when you see an opening. for example, you may call a play that is designed to set up harden for a 3, but maybe someone else will be wide open during the process. dont be afraid to pass it to that open man. take what is there. plays are good because they get your players moving around and moves the defense. you dont always have to run them to the T.
4) high post with dwight howard. call a high post play for him, get him the ball, then press traingle to make him face the basket. use a jap step then launch to get by your man and to the basket. this works all the time for me with monroe, towns, melo. any big man with decent quickness should have success doing this. you could probably have success doing this with josh smith also.
5) pick and roll. you are not going to run a set play everytime down the floor. i know i dont. i freelance quite often actually. but when you do freelance, you need to utilize the pick and roll. it makes the defense move and gets them out of position. it can get you open for mid range shots, it can get you an open lane to the basket or it can leave the roll man wide open. using the pick and roll(or pick and pop if you have a shooting big man) is a must.
6) DONT BE AFRAID OF CONTACT. you are not going to get to the rim with ease using these sliders. you will not be getting wide open dunks or layups all the time. you need to take the contact and get to the free throw line. i shoot like 25 free throws a game playing 11 minute quarters. you should be able to do this with ease while using harden.
7) know when to push the pace. get on the fastbreak as much as possible and try to get easy looks before the defense is set. but also know when to slow it down and run a play.
8) DEFENSE. great defense creates great offense. steals and blocks especially lead to easy buckets in transition.
i hope some of this helps. im currently 9-8 in year two with my knicks, but ive been playing without melo who suffered a broken kneecap after the first 6 games. so im doing pretty well all things considered.