Tweeted ireplakernation (plays a lot of online ranked) and his tip was: I just give them space and stay on my feet. I don't even contest layups, just hands up. I set shot contest to "all".
I'll add to that as I know a few guys have put up some on ball tutorials that could help.
This is an old video by Da Czar but it still holds true today because what he's teaching is defensive fundamentals:
A NBA 2K15 specific tutorial given by JerseyMade93 (jersez on OS):

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