CDC Officials Warn of Coronavirus Outbreaks in the United States.

[mestevo]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Hydroxychloroquine is looking a big swing and a miss.

https://www.salon.com/2020/04/21/trump-touted-hydroxychloroquine-may-increase-risk-of-death-from-covid-19-study-finds/

The researchers looked at the health records of 368 male veterans who were hospitalized with confirmed cases of the new coronavirus. The study also looked at outcomes for patients that received both hydroxychloroquine and the antibiotic azithromycin, a combination repeatedly touted by President Donald Trump. It found that 22% of those patients also died, or twice the rate of patients who did not. The study similarly found no difference in patients who needed a ventilator.

"We found no evidence that use of hydroxychloroquine, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19," the researchers wrote. "An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs."

A Brazilian study published on MedRxiv, a pre-print server for studies awaiting peer review, was also halted earlier this month after 11 of 81 coronavirus patients receiving high doses of hydroxychloroquine died.

Trump has suddenly gone quiet on the drug after repeatedly promoting it at his coronavirus news briefings. The president touted a small French study hyped by Fox News, claiming it had a 100% success rate using the drug in combination with azithromycin to treat the coronavirus. But the study's publisher has since said the research did not meet its standards, and The Guardian reported that researchers excluded several patients who died or were taken to the intensive care unit from the results.

The Centers for Disease Control and Prevention also quietly deleted "unusual" guidance for doctors about using the drug. The CDC now warns that "there are no drugs or other therapeutics approved by the U.S. Food and Drug Administration to prevent or treat COVID-19."

[roadman]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Just think, you heard it first on OS, now hitting my Twitter timeline, lol.


Allen Bored
@TheBoredShow


State of Georgia announces it is re-opening while they have 28-3 lead on COVID-19.

[kehlis]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Whoa lol. Sorry just catching up on OS.

I saw that on Twitter earlier and can't take credit. I don't think it was that guy's but I'm definitely not creative enough to come up with that on my own.

[DaImmaculateONe]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Just think, you heard it first on OS, now hitting my Twitter timeline, lol.


Allen Bored
@TheBoredShow


State of Georgia announces it is re-opening while they have 28-3 lead on COVID-19.

Florida State is wide right behind you...
or left

[SmashMan]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Hydroxychloroquine is looking a big swing and a miss.

Disappointing to hear - obviously any reliable treatment would be great to have.

Shows the importance of testing and verifying before promoting though.

[NYJets]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Too bad about hydroxychlorine.

The other drug we’ve been hearing about lately seems like it could be promising. I forget the name but the one that begins with an R.

Watched a little of the press briefing today dr. Birx definitely didn’t sound like she agreed with what Georgia is doing


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[DieHardYankee26]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

i dont understand why others dont see this either. Ths precedence being set is extremely disconcerting, legit or not. I've seen wicked men take an inch and make it go 5 miles.

Sent from my SM-G950U using Operation Sports mobile app

Because the precedent in this country is slavery and citizen internment camps. What precedent could this possibly bring that would actually be new?

[KSUowls]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Disappointing to hear - obviously any reliable treatment would be great to have.

Shows the importance of testing and verifying before promoting though.

Disappointing, but this is why we can't rush things either. The medical community was urging caution with this drug saying we needed more data.

Being a resident of Georgia...I just don't know what to say about my state. Our governor was resistant to shutting things down in the first place, and now he's opening things back up before the original stay at home order even expires. It's both infuriating and just...

[Sportsforever]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Hydroxychloroquine is looking a big swing and a miss.

https://www.salon.com/2020/04/21/trump-touted-hydroxychloroquine-may-increase-risk-of-death-from-covid-19-study-finds/

The researchers looked at the health records of 368 male veterans who were hospitalized with confirmed cases of the new coronavirus. The study also looked at outcomes for patients that received both hydroxychloroquine and the antibiotic azithromycin, a combination repeatedly touted by President Donald Trump. It found that 22% of those patients also died, or twice the rate of patients who did not. The study similarly found no difference in patients who needed a ventilator.

"We found no evidence that use of hydroxychloroquine, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19," the researchers wrote. "An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs."

A Brazilian study published on MedRxiv, a pre-print server for studies awaiting peer review, was also halted earlier this month after 11 of 81 coronavirus patients receiving high doses of hydroxychloroquine died.

Trump has suddenly gone quiet on the drug after repeatedly promoting it at his coronavirus news briefings. The president touted a small French study hyped by Fox News, claiming it had a 100% success rate using the drug in combination with azithromycin to treat the coronavirus. But the study's publisher has since said the research did not meet its standards, and The Guardian reported that researchers excluded several patients who died or were taken to the intensive care unit from the results.

The Centers for Disease Control and Prevention also quietly deleted "unusual" guidance for doctors about using the drug. The CDC now warns that "there are no drugs or other therapeutics approved by the U.S. Food and Drug Administration to prevent or treat COVID-19."

A friend of mine was literally dying of COVID...had been hospitalized and they were waiting on a vent. Instead, they gave him hydroxychloroquine and in two days he was 100% better and released...I see what this study says, but it obviously works for some people.

[dubcity]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

People playing politics on both sides with regards to that treatment. When it gets to the point of people rooting against something to be effective, idk what to say.

[WaitTilNextYear]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Too bad about hydroxychlorine.

The other drug we’ve been hearing about lately seems like it could be promising. I forget the name but the one that begins with an R.

Watched a little of the press briefing today dr. Birx definitely didn’t sound like she agreed with what Georgia is doing


Sent from my iPhone using Tapatalk

The one you're thinking of is probably remdesivir. This Gilead Sciences drug is already thought to be safe in humans and clinical trials are ongoing. Dropping a link to US News and World Report article here:

https://www.usnews.com/news/health-news/articles/2020-04-21/more-good-news-on-remdesivirs-power-to-treat-covid-19

Here's a link to Gilead's own webpage regarding these clinical trials:

https://www.gilead.com/purpose/advancing-global-health/covid-19/remdesivir-clinical-trials

EDIT: Just wanted to pull out some money quotes from the US News article:

One trial is providing the drug to patients with moderate illness and the other focuses on patients with severe illness.

A number of the patients are now recovering and have been released from the hospital. While it's too early to tell, the researchers said there are also indications that remdesivir can possibly stave off being put on a ventilator.

Remdesivir was originally developed to treat Ebola more than a decade ago. It's known to be generally safe in humans, the researchers said, and is backed by a large body of preclinical research, and a number of studies have shown it stops SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome), the viral cousins of COVID-19.

A study in China earlier this year showed that remdesivir could block COVID-19 from replicating in human cells, and a case report in the New England Journal of Medicine (NEJM) focused on the man in Washington state who was the first known U.S. COVID-19 patient. He received remdesivir, made by Gilead Sciences, and he started improving within 24 hours.

The first results from one of Gilead's compassionate-use trials was published earlier this month in the NEJM. The study showed clinical improvement in two-thirds of patients hospitalized for severe COVID-19 who received the antiviral.

Meanwhile, forthcoming reports from several ongoing clinical trials -- including the ones at Houston Methodist -- will provide more evidence-based data about the use of remdesivir for treating COVID-19 patients.

[WaitTilNextYear]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

A friend of mine was literally dying of COVID...had been hospitalized and they were waiting on a vent. Instead, they gave him hydroxychloroquine and in two days he was 100% better and released...I see what this study says, but it obviously works for some people.

Could be...

Or, he got better in a completely coincidental way. This is why legitimate scientific studies are so important. If we were to go on anecdotal accounts, nothing would ever work reliably and people would be keeling over left and right.

The trouble is we couldn't clone your friend and give one of him the drug and one of him not, and see what happens. This is one of the reasons I am so glad my previous research has never dealt with human test subjects. It is so much more difficult to do.

In any case, glad your friend is better.

[Sportsforever]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Could be...

Or, he got better in a completely coincidental way. This is why legitimate scientific studies are so important. If we were to go on anecdotal accounts, nothing would ever work reliably and people would be keeling over left and right.

The trouble is we couldn't clone your friend and give one of him the drug and one of him not, and see what happens. This is one of the reasons I am so glad my previous research has never dealt with human test subjects. It is so much more difficult to do.

In any case, glad your friend is better.

Absolutely; I read this entire study from cover to cover...I have a hard time deeming it a "legitimate scientific" study just yet. First off, it was not peer reviewed in anyway. Secondly, their study was limited/flawed in ways they acknowledge; every patient was male, over the age of 65, and they couldn't control the pre existing conditions in patients (IOW, of the 97 patients who received hydroxychloroquine, did most of them have asthma, etc).

Finally, as I read through the acknowledgments at the end a name jumped out me; Gilead Sciences. Gilead Sciences provided grant money to this group (not necessarily for this study); Gilead is also the company developing Remdesivir (posted this before I read above where WaitTillNextYear explained who Gilead is). That could be a serious conflict of interest...

Again, not throwing this study out...just saying I'm not ready to rubber stamp it and call it good science. I found it interesting that the group in the study cautions on rushing to judgment on a drug, yet this report seemed to do just that.

[p_rushing]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Absolutely; I read this entire study from cover to cover...I have a hard time deeming it a "legitimate scientific" study just yet. First off, it was not peer reviewed in anyway. Secondly, their study was limited/flawed in ways they acknowledge; every patient was male, over the age of 65, and they couldn't control the pre existing conditions in patients (IOW, of the 97 patients who received hydroxychloroquine, did most of them have asthma, etc).

Finally, as I read through the acknowledgments at the end a name jumped out me; Gilead Sciences. Gilead Sciences provided grant money to this group (not necessarily for this study); Gilead is also the company developing Remdesivir (posted this before I read above where WaitTillNextYear explained who Gilead is). That could be a serious conflict of interest...

Again, not throwing this study out...just saying I'm not ready to rubber stamp it and call it good science. I found it interesting that the group in the study cautions on rushing to judgment on a drug, yet this report seemed to do just that.

It's not a scientific study and the sample size is too small. It also seems that the worst case patients with little chance left were used. Larger studies in France showed it drastically improved conditions in people within 5 days. Those that had to go on ventilators came off of them quickly.

It won't save everyone, it's not a cure, but it definitely helps people recover quickly. There are too many people being told they are heading to a ventilator and it is very serious and then to get better after taking the drug.

I get most scientists won't say it works because they don't have double blind studies across appropriate sample sizes and conditions, but the doctors on the front lines know it works. The question is how well it works across the whole population.

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[mestevo]

Re: CDC Officials Warn of Coronavirus Outbreaks in the United States.

Not completely unexpected, but still yikes.

A person who died at home in Santa Clara County on Feb. 6 was infected with the coronavirus at the time of death, a stunning discovery that makes that individual the first recorded COVID-19 fatality in the United States, according to autopsy results released by public health officials late Tuesday.

That death — three weeks before the first fatality was reported in the U.S., in Washington state on Feb. 28 — adds to increasing evidence that the virus was in the country far earlier than once thought.

Santa Clara County on Tuesday announced three previously unidentified deaths from the coronavirus: the Feb. 6 case, plus one on Feb. 17, which also pre-dates the earlier first fatality, and one on March 6. Initially, the first death in the county had been reported March 9.

People typically die of COVID-19 about a month after they are infected with the coronavirus, suggesting that the person who died Feb. 6 likely was infected in early January.

https://www.sfchronicle.com/health/article/First-known-U-S-coronavirus-death-occurred-on-15217316.php