I use my own set. I also use Coach Mode [auto passing.] I still guide my ball carrier, or may take over the QB and scramble instead of standing still in the pocket all day long. I rarely control defenders. The game is "too easy" when you user control. I have nothing agaisnt user control for fun, but you do have a video game advantage over the computer by seeing the entire field on a play.
Note: Settings are "User/Computer"
Passing
Accuracy: 40/50 - if you still are not using coach mode. 50/50 if you are.
Pass Blocking: 45/30 - Pass Blocking is too good by default, the computer's more so.
Catching: 45/45 - Receivers catch too many passes in Madden in my opinion. Week 1 and 2 was great example of receivers dropping a lot of passes in real life.
Rushing
Broken Tackles: 45/45 - Too many broken tackles in Madden. A slight lowering keeps you and the computer from braking every other tackle.
Blocking: 45/55 Your team blocks too well, the computer not well enough by default.
Fumbles: 47/47 Unless you are using the strip button, there are not many fumbles in Madden. Adrian Peterson holds onto the ball at 50 most of the time.
Run Defense
Recognition: 40/60 - The computer HB needs help running the ball against you because it doesn't have a user to guide him. The computer defense needs help because you
are controlling your back.
Block Shedding: 50/55 - Shedding is fine, in my opinion, for the user. However, the computer gets pushed around a lot on default 50.
Tackling: 55/55 - Again, too many broken tackles for my taste. You still see broken tackles with this setting, but they are not every other play anymore.
Pass Defense
Reaction Time: 50/95 - I used to have user set to 80, but they sniffed everything out and the computer could hardly pass on me even with Brees. The computer pass defense needs all the help it can get, even with Coach Mode.
Interceptions: 25/25 - With high reaction time ,the computer will pick nearly everything. Also, user picks should go down as well. The computer makes a number of bad throws right to your D. you still get picks, but are less likely to average 2-3 or more a game now.
Pass Rush: 60/60 - The pass rush needs to be more effective than it is by default. This increase with the lowered pass blocking makes the user and computer QBs feel the pressure far more often. Having "all day to throw" is far less common, like real life.
I also use Fatigue at 57, and normal game speed. I also tell players to substitute out at around 75 or so fatigue and come back in at 85 or so. Offensive linemen and QB's I tell to stay in a little longer than 75. More like 70. That way you also get a more realistic rotation and depth is needed.
These sliders work for
me. When I use the Bills, I can hardly move the ball. When I have the Jets, I can run the ball really well, and am average at the pass. When I use the Colts, I can pass all day and mix in the run. I had a franchise from back when I got the game where 49ers rookies Mike Upati and Anthony Davis have progressed to 90+ OVR players, we have Joe Staley, and I drafted a RG in the first off season who is a 95 OVR stud. I also found a FB with a lot of run blocking strength and impact blocking. After exporting the team and playing exhibition games, my running game is amazing, but my passing game is still suspect, as it should be. My line plows the road for me on nearly every down. I compare that to going back and using the Bills where C.J. Spiller has to do all the work himself, and I can see and feel the difference between a good line and a bad one.
I suggest you try these out, and try many different match ups. Then replay those match ups as the other teams. After some games, make any tweaks you may feel you need.